The Amazing Spider-Man #663

Part of the "Infested: The Road to Spider-Island" banner, this 2011 issue finds Spider-Man crouching in the foreground while a purple-costumed figure rises dramatically behind him — and looming over them both is the fearsome white-and-black form of Anti-Venom, tendrils of symbiote swirling outward against a churning, ghostly background. Frank Cho's cover work captures a real sense of layered tension, with three distinct presences stacked in a composition that feels genuinely ominous. Dan Slott kicks off "The Return of Anti-Venom" here, with art by Giuseppe Camuncoli inked by Klaus Janson and colored by Matt Hollingsworth.