The Amazing Spider-Man #633

Part four of Zeb Wells's "Shed" story arc delivers one of 2010's most viscerally striking covers, penciled by Chris Bachalo and inked by Tim Townsend: Spider-Man is caught helplessly in the crushing jaws of what appears to be a monstrous, scaled creature — teeth, debris, and darkness closing in from every angle. The sheer scale of the beast dwarfs our hero completely, making the situation feel genuinely dire. If this arc has been building dread, this cover suggests it has arrived in full force.