The Amazing Spider-Man #684

Part of the celebrated "Ends of the Earth" arc, this 2012 chapter puts Spider-Man in dire straits as the cover shows him face-down and barely conscious in a swirling desert landscape. Towering above is a massive sand-formed giant, while Black Widow fights desperately through the storm and a silver-haired figure — Silver Sable — is caught up in the churning wave of debris. Stefano Caselli's cover work conveys real scale and urgency, and the creative team of Dan Slott, Humberto Ramos, Victor Olazaba, and Edgar Delgado delivers the kind of globe-spanning superhero adventure that made this run memorable.