The Amazing Spider-Man #676

Spider-Man scrambles across a glass surface in his striking black-and-orange suit while a massive, grey-skinned brute looms behind him — and that's just one of several menacing figures crowding the edges of this cover by Humberto Ramos. The bold tagline promises "The Sinister Six Take Over!", making it clear our wall-crawler is dangerously outnumbered. Dan Slott and Ramos bring their signature kinetic energy to this 2012 installment, and that cheeky speech bubble — "If you don't read this comic… the bad guys win!" — is hard to argue with.