Dark Reign: Mister Negative #2

The second chapter of this 2009 Marvel limited series puts Spider-Man front and center — rendered in a haunting negative-image color scheme, his suit inverted to stark black and white as he crouches amid a tangle of jagged, thorn-like tendrils that claw at him from every direction. Jae Lee's cover art lends the scene an eerie, almost otherworldly atmosphere, perfectly evoking the corrupting influence of Mr. Negative that hangs over the "Dark Reign" era. If you're following "Battle for Chinatown," this striking visual alone sets the tone for the conflict within.