Ultimate Spider-Man #93

The third chapter of the "Deadpool" arc arrives in this 2006 installment of Ultimate Spider-Man, with Mark Bagley's cover putting the Merc with a Mouth front and center — red-suited, sword raised high in one hand and a firearm gripped in the other, all attitude and menace against a stark yellow backdrop. Brian Michael Bendis and Bagley were deep into one of the most celebrated creative runs in Marvel history by this point, and the tension building across this four-part story is palpable just from that single striking image. If you've been following the arc, this is exactly the kind of cover that makes you want to flip straight to page one.