Superman - Action Comics #4
In "Hybrid, Part 1," Superman awakens to find the alien virus that infected his hand has been rejected by his body—only for the virus to take on a life of its own, manifesting as a violent, self-replicating threat. Written by Andy Diggle and Tony S. Daniel, with art by Tony S. Daniel and Batt, this pivotal issue sees Superman and Shay Veritas battle the emerging Hybrid, but as the creature's influence spreads, more of Metropolis falls prey to its transformation. The cover by Tony S. Daniel and Batt captures the eerie, escalating tension of a city on the brink.
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Superman wakes up to learn the virus that attacked his hand was rejected by his body. But the virus creates its own body and attacks. Superman and Shay Veritas defeat the Hybrid, but others in Metropolis are infected and also transform. Lex Luthor observes his work and gloats.
Plot details indexed by the Grand Comics Database (CC BY-SA).