Action Comics #20
In "Hybrid, Part 2," Superman awakens to find his body has rejected the alien virus, only for the pathogen to take on a life of its own—turning against him. As he battles the monstrous Hybrid alongside Shay Veritas, the infection spreads through Metropolis, turning others into new threats. Lex Luthor watches from the shadows, satisfied with the chaos he's unleashed. Written by Andy Diggle and Tony S. Daniel, with art by Tony S. Daniel and Matt Banning, and a cover by Tony S. Daniel and Matt Banning, this 2013 issue delivers a tense, body-horror-infused escalation in Superman’s fight against an enemy that’s both alien and terrifyingly familiar.
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Superman wakes up to learn the virus that attacked his hand was rejected by his body. But the virus creates its own body and attacks. Superman and Shay Veritas defeat the Hybrid, but others in Metropolis are infected and also transform. Lex Luthor observes his work and gloats.
Plot details indexed by the Grand Comics Database (CC BY-SA).