Ringo's Indian friend Dull Knife is shot while preventing a stage robbery. The town doctor is happy to help, but small-minded citizens want him to stop treating non-whites, so he quits his practise and leaves town. But upon learning that the two worst offenders, Wyatt and Spanner, have contracted the red plague, Doc returns. When it is discovered that the medicine needed has been stolen from the stage, the pair confess to the robbery, naming Sam Yates as their partner. They find the medicine in Yates' shack and the plague is averted. A new spirit of racial tolerance is evident.

Plot details indexed by the Grand Comics Database (CC BY-SA).