B.P.R.D., Plague of Frogs

From 2004, Mike Mignola and Guy Davis expanded the Hellboy universe at Dark Horse with B.P.R.D.: Plague of Frogs, a five-issue series that shifted the focus from its founding demon to the Bureau's human and inhuman agents. This arc launched the Bureau's battle against a creeping, amphibious apocalypse, establishing Davis's gritty, textured art as a defining visual for the team's long-running horror saga. It matters as the pivotal story that transformed the Hellboy spin-off into its own epic, character-driven monster-fighting chronicle.