What If? Secret Invasion #1
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The Skrulls have taken over and provided willing humans with their DNA, allowing humans to live long, healthy lives. Wolverine brings the resistance the Skrull-laced Legacy Virus which Spider-Man, Night Thrasher and Iron Man try to modify so that all of the partially Skrull humans won’t be killed. The heroes are attacked as Iron Man proclaims the virus ready. Thor uses a hurricane to distribute the virus but it ends up killing both the Skrulls and modified humans. Iron Man is revealed as Norman Osborn who replaced Stark. Captain America beheads Norman and the heroes are arrested by UN forces.
Plot details indexed by the Grand Comics Database (CC BY-SA).