Poison

Steve Gerber and Cynthia Martin introduced Poison to Marvel readers in 1988's Web of Spider-Man Annual #4, right at the cusp of the Copper Age, and this darkly named figure has lingered in the Marvel universe across an impressive 35-year span. With appearances spread across Marvel Comics Presents and collections anchoring major Marvel events like the Evolutionary War, Poison clearly carved out a niche in the grittier corners of the publisher's lineup. The character keeps genuinely compelling company — sharing pages with Wolverine and the likes of Slug and Ulysses Luggman — signaling a world of street-level menace and moral complexity. Fifteen catalog appearances over three-and-a-half decades make Poison a rewarding discovery for collectors who love digging into Marvel's deeper cuts.