Ultimate Six #6

Spider-Man dominates the cover of this 2004 Marvel series, caught mid-struggle as a powerfully built, long-haired brute grabs him by the leg and strains against his grip. The raw physicality of the image — rendered with real dynamism by cover artist John Cassaday — makes clear that Peter Parker's wall-crawling skills alone may not be enough here. With Brian Michael Bendis writing and Trevor Hairsine on interior art, Ultimate Six #6 arrives at what feels like a pivotal clash between the web-slinger and a very dangerous opponent.