The Powerpuff Girls #27
In "Bless This Mess," the Powerpuff Girls face a surprisingly sticky situation when the Professor bans them from going outside until their room is clean—just as Him sees a chance to exploit their distraction. With every attempt to tidy up, the mischievous villain sabotages their efforts, turning their room into a chaotic trap. Written by Brett Lewis and illustrated by Christopher Cook, with inks by Mike DeCarlo and colors by Dave Tanguay, this 2002 DC issue features a cover by Phil Moy.
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When the Professor insists that the Powerpuff Girls must clean their room before they can go outside to play (or to save Townsville), Him comes up with an evil plot to keep them out of his way -- every time they turn their backs, he messes up their room again!
Plot details indexed by the Grand Comics Database (CC BY-SA).