Spider-Man / Deadpool #3

In "Itsy Bitsy, Part 1," the deadly little assassin known only as Itsy Bitsy turns her sights on her creators—Spider-Man and Deadpool—after being unleashed by Patient Zero, launching a brutal campaign that targets Spider-Man’s rogues gallery. With precision and chilling calm, she proves she’s not just a pawn, but a force all her own.

In "Itsy Bitsy, Part 2," Spider-Man and Deadpool close in on the truth as Patient Zero finally begins to speak—only for the mysterious Itsy Bitsy to cut the revelation short in a brutal, shocking moment. The tension crackles as secrets hang in the balance, and the duo must react before the next move.

In "Itsy Bitsy, Part 4," Spider-Man trains with Nightcrawler as they prepare to confront the escalating threat of Itsy Bitsy, forcing Nightcrawler to grapple with the painful choice of whether he must end her life to stop her rampage. Meanwhile, Patient Zero’s true identity is revealed—Weasel, Deadpool’s former friend—whose cryptic final words hint at a deeper connection to the masked mercenary.

In "Itsy Bitsy, Part 6," Spider-Man finds himself caught in a web spun by Mephisto, who’s been pulling strings through Weasel to corrupt the web-slinger’s soul—only for Deadpool’s unexpected decency to throw the devil’s plan into chaos.