Spider-Girl #90

The cover of Spider-Girl #90 lays out a genuinely unsettling family crisis: a giant, monstrous version of Spider-Girl — her costume warped and her head transformed into something feral and terrifying — looms over a cityscape as military helicopters circle in the smoky distance. Below her, Peter and Mary Jane Parker argue in desperate tones, their dialogue bubbles spelling out the heartbreak: he insists she must be destroyed, while Mary Jane reminds him she's still their daughter. With Ron Frenz penciling and Sal Buscema inking the cover, and Tom DeFalco steering the story in 2005, this issue promises a deeply personal kind of horror that hits harder than any outside villain ever could.