Spider-Girl #82

The cover of Spider-Girl #82 makes the stakes immediately clear: a massive, grinning Venom dominates the frame, tongue lashing out as Spider-Girl and a terrified civilian scramble to escape those enormous, razor-sharp jaws. Billed as "Inside the Beast! Part 1 of 3," this 2005 Marvel issue signals the start of a three-part arc from the creative team of Tom DeFalco, Ron Frenz, and Sal Buscema, with cover art by Pat Olliffe and Al Williamson. If you've ever wanted to see May Parker face one of Marvel's most menacing symbiotes, this is a compelling place to start.