Friendly Neighborhood Spider-Man #3

Part 7 of the sprawling 12-part "The Other: Evolve or Die" crossover, this 2006 Marvel issue presents a genuinely unsettling cover by Mike Wieringo and Karl Kesel — a battered, upside-down Spider-Man hangs limply in his torn costume, medical tubing attached, while masked figures that appear to be doctors or surgeons loom in the glowing background. The monochromatic, almost ghostly palette gives the whole image a haunting, clinical weight that feels worlds away from your typical wall-crawling adventure. J. Michael Straczynski writes, with interior art by Mike Wieringo, making this a compelling chapter in one of Spider-Man's most ambitious mid-2000s storylines.