All Star Superman #4

Frank Quitely's cover for this 2006 DC gem sets the stakes immediately: a glowing-eyed Superman hoists a massive SUV overhead while a wild-haired Jimmy Olsen scrambles away clutching a futuristic syringe-like weapon, debris exploding around his feet. The cover copy asks point-blank whether the Superman/Olsen team is finished — declaring flatly that "Superman's Turned Evil!" — while Jimmy's speech bubble makes clear he's banking everything on those strange future weapons just to survive. Grant Morrison and Quitely were deep into their All Star Superman run by issue four, and this cover promises that their storytelling ambition hadn't slowed down one bit.