52 Aftermath: The Four Horsemen #1

Rising from a hellish inferno of fire and chaos, the four towering monstrosities of the title loom over Wonder Woman, Superman, and Batman — who stand resolute and impossibly small against the apocalyptic threat surrounding them — in a cover rendered with striking intensity by Ethan Van Sciver. This October 2007 first issue of six kicks off the 52 aftermath miniseries, with Keith Giffen writing and Pat Olliffe and John Stanisci handling interior art. If you've ever wanted to see DC's trinity face down something genuinely nightmarish, this opening chapter makes a compelling case for picking up the full run.