Spider-Man/Deadpool

Marvel's oddest couple got their own ongoing series in 2016, pairing the wisecracking wall-crawler with the merc with a mouth for a wild ride that lasted 39 issues. Written primarily by Joe Kelly, this book leaned hard into the duo's chaotic chemistry, blending superhero action with meta humor and genuine heart. It matters because it turned a gimmick team-up into a surprisingly deep exploration of heroism and friendship, all while delivering some of the most entertaining banter in modern comics.