The originalheld the mantle from 1963
Dr. Curtis "Curt" Connors
Powers. As the Lizard: superhuman strength/speed/agility/durability, regeneration, claws/fangs/scales, prehensile tail, telepathic control over reptiles. Connors himself is a brilliant geneticist/herpetologist.
Origin
Dr. Curtis Connors, a brilliant reptile biologist who lost his right arm, developed a serum derived from lizard DNA in hopes of regenerating his missing limb — but the formula transformed him instead into the savage, cold-blooded Lizard, bringing him into conflict with Spider-Man in their very first encounter.