The Spectacular Spider-Man #220

Mary Jane Watson dominates this striking 1995 cover with a knowing smile and arms crossed, delivering her trademark line — "Tiger, do I have news for you!" — against a bold blue backdrop while a tiny Spider-Man swings in the upper corner. Part 2 of the "Web of Death" arc, this giant-sized flip book carries real anticipation with it, the kind of charged energy that comes from a story building toward something significant. Sal Buscema handles both pencils and inks on the cover, giving Mary Jane a confident, glamorous presence that makes you want to find out exactly what news she's bringing to Peter Parker.