She-Hulk #14

Dan Slott and Rick Burchett's 2007 run on She-Hulk had a gift for humanizing the Marvel Universe's more unusual corners, and issue #14 spotlights that perfectly. Greg Horn's cover presents a poignant, worm's-eye view of the grey-skinned, casually dressed Awesome Andy standing on a chalkboard that reads "Goodbye Cruel World…" — a big, powerful figure rendered quietly vulnerable against a rain-streaked city backdrop. It's a genuinely affecting image that sets an unexpectedly emotional tone for a story promising to dig into everything you ever wanted to know about one of Marvel's most endearing gentle giants.