Marvel Universe Ultimate Spider-Man #16

Spider-Man finds himself in the most precarious of positions on Ty Templeton's cover — literally trapped inside Venom's enormous, drool-slicked jaws, surrounded by rows of jagged teeth as the symbiote's massive black form dominates the entire image. It's a genuinely unsettling composition that puts our wall-crawling hero at his most vulnerable, with nowhere to swing and no easy escape in sight. Paired with the story title "Back in Black," this 2013 issue promises a tense confrontation between Spider-Man and one of his most formidable foes.