Madame Hydra

Emerging from the shadows of Marvel's Modern Age, Madame Hydra made her catalog debut in the landmark Secret Warriors #1 (2009), brought to life by the powerhouse creative team of Brian Michael Bendis, Jonathan Hickman, and Stefano Caselli. Her appearances span New Avengers alongside some of Marvel's heaviest hitters — Logan, Luke Cage, Matt Murdock, and Carol Danvers — which tells you everything about the high-stakes world she inhabits. With a key issue already to her name despite a compact presence in the catalog, she's a figure whose every appearance carries weight, the kind of character serious collectors keep a close eye on.