Brain

A diabolical little genius with big ambitions, Brain made his comics debut in Superman & Batman Magazine #8 in 1995, brought to four-color life by the sharp creative pairing of Roger Stern and Ty Templeton. This DC character shares his pages with heavy-hitters like Batman, Bruce Wayne, and The Flash — not bad company for a lab mouse with delusions of world domination — and his frequent companion Pinky is never far behind. With appearances spanning Pinky and the Brain and even a Batman Beyond Special Origin Issue, and one collector-recognized key issue to his name, Brain may have a compact comics footprint, but every appearance counts when you're this determined.