Alkhema

Debuting in Avengers #0 in 1999 under the masterful guidance of Kurt Busiek and Stuart Immonen, Alkhema is a Marvel villain who carved out a genuinely unsettling corner of the Copper/Modern Age. Her catalog footprint is compact but choice — sharing pages with heavyweights like Iron Man, the Scarlet Witch, and Hank Pym — and her starring role in Avengers: The Ultron Imperative marks her as a figure significant enough to anchor her own chapter of Marvel history. Rare appearances and an Official Handbook entry of her own make Alkhema exactly the kind of deep-cut discovery that rewards the devoted collector digging past the household names.